I suppose the secondary market does dictate price to a certain extent. Variables to consider when pricing cards include team, player, serial numbered or not, availability and number produced.
Recent examples are World Cup Heroes Parallels from 14 Elite. Very popular, prices started low and sky rocketed. Had these been serial numbered the prices would have been significantly more.
13 Traders, generally considered to be a poor release but unnumbered YG signatures and the Legends, hand numbered and still /208 command better prices than YG signatures serial numbered to half the 13 Traders run