In certain circumstances ..... yeah, i've done it. If a card is serially numbered then - technically - each card in the print run for that particular product for that particular year is unique. When it comes to jersey cards .... if i can get different colour swatches, i'll do it (I've got the Garnett T'wolves rainbow for his 2004-05 Hoops Great Shots Jersey hobby card -blue,black,white). Other than that .... if there is a clear difference in some aspect of the cards (variations in colour, foil, etc) i'll for sure get multiples. Defining clear comes down to how anally retentive you want to get....lol